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World Journal of Surgical Oncology - Latest Articles
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The latest research articles published by World Journal of Surgical Oncology
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Struma ovarii with follicular thyroid-type carcinoma and neuroendocrine component: case report
Struma ovarii (SO) is a slow-growing ovarian neoplasm with thyroid tissue as itspredominant component. It is an uncommon neoplasm, usually asymptomatic with anunknown risk of malignant transformation. Due to difficulties in assessing the rare biologicalnature and the discrepancies in the reported cases, a consensus on the appropriate treatmenthas not been definitively reached.A 50-year-old female was subjected to upper gut endoscopy which showed a 30-mm masslocated in the gastric antrum, suggestive of mesenchimal tumor. Incidentally, a pelvic CTscan also documented a solid mass in the right adnexa, with morphological characteristics ofovarian neoplasm. The patient underwent gastrectomy, total hysterectomy, bilateral salpingooophorectomywith lymph node dissection, and omentectomy. Histology documented thepresence of gastric cavernous angioma, and, in the right adnexa, foci of follicular thyroidtypecarcinoma arising in SO with a well-differentiated neuroendocrine component.Here we report and discuss the clinical and morphological presentation of follicular thyroidtypecarcinoma arising in SO. The neoplasm was discovered incidentally and had a favorableclinical outcome at 1-year follow-up.
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Expression levels of HMGA2 and CD9 and its clinicopathological significances in the benign and malignant lesions of the gallbladder
Background:
The objective of this study was to investigate CD9 and HMGA2 expression and itsclinicopathological significance in benign and malignant lesion tissues of the gallbladder.
Methods:
The resected specimens of 108 cases of gallbladder adenocarcinoma, 46 cases of adjacenttissue, 15 cases of polyps and 35 cases of chronic cholecystitis were made into conventionalparaffin-embedded sections, using the method of EnVision immunohistochemistry to stainHMGA2 and CD9.
Results:
HMGA2 expression of gallbladder adenocarcinoma was significantly higher than that ofadenocarcinoma adjacent tissues (= 16.13, P <0.01), polyps (= 8.19, P <0.01) and chroniccholecystitis (= 21.41, P <0.01); but CD9 expression was the opposite (P <0.05 or P <0.01).The positive rate of HMGA2 expression from the cases that had well-differentiatedadenocarcinoma, with the largest tumor diameter <2 cm, and without lymph node metastasis,and that did not invade the surrounding tissue was significantly lower than that of HMGA2expression from the cases that had poorly differentiated adenocarcinoma, with the largesttumor diameter [greater than or equal to]2 cm, lymph node metastasis, and that invaded the surrounding tissues (P<0.05 or P <0.01). The positive rate of CD9 expression from the cases that had welldifferentiatedadenocarcinoma, with the largest tumor diameter <2 cm, and without lymphnode metastasis, and that did not invade the surrounding tissue was significantly higher thanthat of CD9 expression from the cases that had poorly differentiated adenocarcinoma, withthe largest tumor diameter [greater than or equal to]2 cm, lymph node metastasis, and which invaded the surroundingtissues (P <0.05 or P <0.01). The Kaplan-Meier survival analysis showed that after surgery,the survival period of HMGA2 expression-positive cases was significantly lower than that ofHMGA2 expression- negative cases (P = 0.020), but the survival period of CD9 expressionpositivecases was significantly higher than that of cases with CD9 expression-negative (P =0.019). Cox multivariate regression analysis showed that the HMGA2 positive expressionand/or CD9 negative expression was an important indicator reflecting the poor prognosis ofgallbladder cancer.
Conclusion:
The expression of HMGA2 and/or CD9 might be closely related to the carcinogenesis,clinical biological behaviors and prognosis of gallbladder adenocarcinoma.
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Case report: lymphoepithelial-like carcinoma of the lung-a chronic disease?
This is a case of metastatic lung cancer of the lymphoepithelial-like carcinoma (LELC)variant who first presented with symptomatic brain metastasis. The patient underwent localand systemic treatment for metastatic disease with good clinical outcome. The patient wasdisease free for four years then she had primary lung recurrence which was surgicallyresected. She underwent a second course of chemotherapy with saw her through another twoyears of disease free period. A recurrence of the cancer was detected intra-abdominally on theseventh year of diagnosis. This was treated again with surgical resection and another courseof chemotherapy.
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Ocular melanoma in a patient successfully treated for diffuse malignant peritoneal mesothelioma: a case report
Background:
Diffuse malignant peritoneal mesothelioma and ocular melanoma are both rare tumors. Tothe best of our knowledge there is only one previous report of three cases in a family withknown susceptibility to malignancies associating diffuse malignant peritoneal mesotheliomaand ocular melanoma, with no sporadic cases previously reported.Case presentationWe describe the case of a 59-year-old man with a history of diffuse malignant peritonealmesothelioma, who presented with ocular melanoma 41 months after cytoreductive surgeryand hyperthermic intraperitoneal chemotherapy. We also briefly review the literature.
Conclusions:
Diffuse malignant peritoneal mesothelioma is an uncommon but aggressive disease. Asdiffuse malignant peritoneal mesothelioma characteristically remains confined to theabdominal cavity, any new extra-abdominal symptom should eventually raise suspicion ofanother primary tumor. Few cases of diffuse malignant peritoneal mesothelioma associatedwith other primary tumors have been reported. As ocular melanoma is also infrequent, wesuspect a genetic predisposition to these tumors. There is emerging evidence supporting therole of BAP1 mutations in the pathogenesis of these two neoplasias.
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The effect of laparoscopic surgery in stage II and III
right-sided colon cancer: a retrospective study
Background:
This retrospective study compared the clinicopathological results among three groups dividedby time sequence to evaluate the impact of introducing laparoscopic surgery on long-termoncological outcomes for right-sided colon cancer.
Methods:
From April 1986 to December 2006, 200 patients who underwent elective surgery with stageII and III right-sided colon cancer were analyzed. The period for group I referred back to thetime when laparoscopic approach had not yet been introduced. The period for group II wasdesignated as the time when first laparoscopic approach for right colectomy was carried outuntil we overcame its learning curve. The period for group III was the period afterovercoming this learning curve.
Results:
When groups I and II, and groups II and III were compared, overall survival (OS) did notdiffer significantly whereas disease-free survival (DFS) in groups I and III were statisticallyhigher than in group II (P = 0.042 and P = 0.050). In group III, laparoscopic surgery had atendency to provide better long-term OS (P = 0.2036) and DFS (P = 0.2356) than opensurgery. Also, the incidence of local recurrence in group III (2.6%) was significantly lowerthan that in groups II (7.4%) and I (12.1%) (P = 0.013).
Conclusions:
Institutions should standardize their techniques and then provide fellowship training fornewcomers of laparoscopic colon cancer surgery. This technique once mastered will becomethe gold standard approach to colon surgery as it is both safe and feasible considering theoncological and technical aspects.
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