Brand Names: U.S.
- Acne Products;
- Topical Skin Product;
- Topical Skin Product, Acne
Epiduo®: Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)
Postmarketing and/or case reports: Blistering, conjunctivitis, eczema, eyelid edema, facial swelling, pain, photosensitivity, pruritus, rash, skin discoloration
• Bleaching effects: May bleach hair or colored fabric.
• Photosensitivity: Use is associated with increased susceptibility/sensitivity to UV light; avoid sunlamps or excessive sunlight exposure. Daily sunscreen use and other protective measures are recommended.
• Skin irritation: Certain cutaneous signs and symptoms (eg, erythema, dryness, scaling, burning/stinging) may occur during treatment; these are most likely to occur during the first 4 weeks and usually lessen with continued use. Use of moisturizer, decreased use, or discontinuation may be recommended.
Concurrent drug therapy issues:
• Topical acne product: Use concomitant topical acne therapy with caution; cumulative irritancy may occur.
• Appropriate use: For external use only; avoid contact with abraded skin, mucous membranes, and eyes.
Contraceptives (Progestins): Retinoic Acid Derivatives may diminish the therapeutic effect of Contraceptives (Progestins). Retinoic Acid Derivatives may decrease the serum concentration of Contraceptives (Progestins). Management: Two forms of effective contraception should be used in patients receiving retinoic acid derivatives. Particularly, microdosed progesterone-only preparations may be inadequately effective. Risk D: Consider therapy modification
Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Risk C: Monitor therapy
Vitamin A: May enhance the adverse/toxic effect of Retinoid-like Compounds. Risk D: Consider therapy modification
There are no well-controlled studies in pregnant women. Use only if benefit outweighs the potential risk to fetus.
- Epiduo (AR, AU, BE, BR, CH, CO, DE, DK, FI, FR, GB, HK, IT, KP, MY, NO, PH, PL, PT, SE, SG)
Adapalene is a retinoid-like compound which is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of which represent important features in the pathology of acne vulgaris.
Metabolism: Benzoyl peroxide: Converted to benzoic acid in skin
Excretion: Adapalene: Primarily through bile; Benzoyl peroxide: Urine