Drug Information

Adapalene and benzoyl peroxide

Adapalene and benzoyl peroxide
Copyright 1978-2011 Lexicomp, Inc. All rights reserved.

Brand Names: U.S.

  • Epiduo®
Brand Names: Canada

  • Tactuo™
Pharmacologic Category

  • Acne Products;
  • Topical Skin Product;
  • Topical Skin Product, Acne
Dosing: AdultAcne vulgaris: Topical: Apply once daily to affected areas after skin has been cleaned and dried

Dosing: PediatricChildren ≥12 years: Refer to adult dosing.

Dosing: GeriatricRefer to adult dosing.

Dosage Forms: U.S.Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Gel, topical:

Epiduo®: Adapalene 0.1% and benzoyl peroxide 2.5% (45 g)

Generic Equivalent Available: U.S.No

AdministrationApply a pea-sized amount for each area of the face (eg, forehead, chin, each cheek). Skin should be clean and dry before applying. For external use only; avoid applying to eyes and mucous membranes.

UseTopical treatment of acne vulgaris

ContraindicationsThere are no contraindications listed in the manufacturer’s labeling.

Warnings/Precautions Concerns related to adverse effects:

• Bleaching effects: May bleach hair or colored fabric.

• Photosensitivity: Use is associated with increased susceptibility/sensitivity to UV light; avoid sunlamps or excessive sunlight exposure. Daily sunscreen use and other protective measures are recommended.

• Skin irritation: Certain cutaneous signs and symptoms (eg, erythema, dryness, scaling, burning/stinging) may occur during treatment; these are most likely to occur during the first 4 weeks and usually lessen with continued use. Use of moisturizer, decreased use, or discontinuation may be recommended.

Concurrent drug therapy issues:

• Topical acne product: Use concomitant topical acne therapy with caution; cumulative irritancy may occur.

Other warnings/precautions:

• Appropriate use: For external use only; avoid contact with abraded skin, mucous membranes, and eyes.

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Contraceptives (Progestins): Retinoic Acid Derivatives may diminish the therapeutic effect of Contraceptives (Progestins). Retinoic Acid Derivatives may decrease the serum concentration of Contraceptives (Progestins). Management: Two forms of effective contraception should be used in patients receiving retinoic acid derivatives. Particularly, microdosed progesterone-only preparations may be inadequately effective. Risk D: Consider therapy modification

Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Risk C: Monitor therapy

Vitamin A: May enhance the adverse/toxic effect of Retinoid-like Compounds. Risk D: Consider therapy modification

Pregnancy Implications

There are no well-controlled studies in pregnant women. Use only if benefit outweighs the potential risk to fetus.

LactationExcretion in breast milk unknown/use caution

International Brand Names

  • Epiduo (AR, AU, BE, BR, CH, CO, DE, DK, FI, FR, GB, HK, IT, KP, MY, NO, PH, PL, PT, SE, SG)
Pharmacodynamics/KineticsAbsorption: Via the skin

Metabolism: Benzoyl peroxide: Converted to benzoic acid in skin

Excretion: Adapalene: Primarily through bile; Benzoyl peroxide: Urine