Brand Names: U.S.
- Antiviral Agent, Topical;
- Corticosteroid, Topical
• Sensitization: Use has been associated with local sensitization (irritation).
• Herpes labialis: Appropriate use: Treatment should begin with the first signs or symptoms. For external use only to the lips and around the mouth; do not apply to eye, inside the mouth or nose, or on the genitals. Contact healthcare provider if cold sore does not heal in 2 weeks.
• Immunocompromised patients: Use with caution in immunocompromised patients.
Conivaptan: May increase the serum concentration of CYP3A4 Substrates (Low risk). Risk C: Monitor therapy
Corticorelin: Corticosteroids may diminish the therapeutic effect of Corticorelin. Specifically, the plasma ACTH response to corticorelin may be blunted by recent or current corticosteroid therapy. Risk C: Monitor therapy
Deferasirox: Corticosteroids may enhance the adverse/toxic effect of Deferasirox. Specifically, the risk for GI ulceration/irritation or GI bleeding may be increased. Risk C: Monitor therapy
Telaprevir: May increase the serum concentration of Corticosteroids. Corticosteroids may decrease the serum concentration of Telaprevir. Management: Concurrent use of telaprevir and systemic corticosteroids is not recommended. When possible, consider alternatives. If used together, employ extra caution and monitor closely for excessive corticosteroid effects and diminished telaprevir effects. Risk D: Consider therapy modification
Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates. Risk C: Monitor therapy
Animal reproduction studies and studies in pregnant women have not been conducted with Xerese™. Systemic exposure of acyclovir and hydrocortisone after topical administration is minimal. See individual agents.
Hull CM, Harmenberg J, Arlander E, et al, “Early Treatment of Cold Sores With Topical ME-609 Decreases the Frequency of Ulcerative Lesions: A Randomized, Double-Blind, Placebo-Controlled, Patient-Initiated Clinical Trial,” J Am Acad Dermatol, 2011, 64(4):696.e1-11. [PubMed 20851499]