Drug Information

Progestin for Dysfunctional Uterine Bleeding

Progestin for Dysfunctional Uterine Bleeding


Progestins, synthetic versions of the hormone progesterone , are used to treatdysfunctional uterine bleeding . They are given either as high-dose progestin pills or in the form of birth control pills.

Oral (pill)

Generic Name Brand Name
medroxyprogesterone Provera
norethindrone Micronor
progesterone Prometrium

The levonorgestrel intrauterine device (IUD) is also a progestin treatment for dysfunctional uterine bleeding. This type of IUD  continually releases levonorgestrel, a form of progesterone , into the uterus.

How It Works

Progestins prevent overgrowth of the endometrium . This helps preventdysfunctional uterine bleeding . (Heavy bleeding is often the product of irregular breakdown of an overgrown endometrium.) In teens and women who aren’tovulating  regularly, progestins help restore a predictable monthly menstrual period .

You usually take progestins 10 to 12 days every month.

How Well It Works

Progestin therapy effectiveness varies with the type of dysfunctional uterine bleeding treated and the dosage and timing of treatment.

Side Effects

All medicines have side effects. But many people don’t feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

  • Usually the benefits of the medicine are more important than any minor side effects.
  • Side effects may go away after you take the medicine for a while.
  • If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call 911 or other emergency services right away if you have:

  • Trouble breathing.
  • Swelling of your face, lips, tongue, or throat.
SEE MORE:  Cyclosporine for Inflammatory Bowel Disease

Call your doctor if you have:

  • Hives.

Common side effects of this medicine include:

  • Absence of menstrual bleeding (amenorrhea).
  • Abnormal vaginal bleeding, such as irregular spotting to light vaginal bleeding.
  • Abdominal (belly) pain.
  • Breast tenderness.
  • Dizziness.
  • Mood changes.
  • Swelling of face, ankles, or feet.
  • Weight gain.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Taking medicine

Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don’t take your medicines properly, you may be putting your health (and perhaps your life) at risk.

There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.

SEE MORE:  Anticholinergics for Urinary Incontinence in Spinal Cord Injuries

Advice for women

If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.


Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It’s also a good idea to know your test results and keep a list of the medicines you take.




  1. Lobo RA (2007). Abnormal uterine bleeding: Ovulatory and anovulatory dysfunctional uterine bleeding, management of acute and chronic excessive bleeding. In VL Katz et al., eds., Comprehensive Gynecology, 5th ed., pp. 915–931. Philadelphia: Mosby Elsevier.

Last Revised: June 1, 2012

Author: Healthwise Staff

Medical Review: Sarah Marshall, MD – Family Medicine & Andrew Swan, MD, CCFP, FCFP – Family Medicine & Kirtly Jones, MD – Obstetrics and Gynecology