Acetaminophen, chlorpheniramine, phenylephrine, and phenyltoloxamine: Patient drug information
Copyright 1978-2011 Lexicomp, Inc. All rights reserved.
(For additional information see “Acetaminophen, chlorpheniramine, phenylephrine, and phenyltoloxamine: Drug information”)
Brand Names: U.S.
Alpha-Adrenergic Agonist ;
Histamine H1; Antagonist
Histamine H1 Antagonist, First Generation
What key warnings do I need to know about before using this drug?
• Unsafe side effects may happen. This drug cannot be taken while you are taking some other drugs. Check all the drugs you are taking with your doctor.
When is it not safe to use this drug?
• If you have an allergy to acetaminophen, chlorpheniramine, phenylephrine, phenyltoloxamine, or any other part of this drug.
• Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have any of these health problems: Asthma, glaucoma, or very high blood pressure.
What is this drug used for?
• It is used to ease allergy signs.
• It is used to ease pain.
• It is used to treat nose stuffiness.
How does this drug work?
• Acetaminophen blocks chemicals that cause pain.
• Chlorpheniramine and phenyltoloxamine lowers or stops the body’s reaction to the allergen.
• Phenylephrine shrinks swollen nose tissue and opens up passages.
How is this drug best taken?
• Do not take more than what your doctor told you to take. Liver problems may happen.
• This drug is most useful if started before contact with the allergen. Take at least 1 to 3 hours before.
• Do not chew or crush.
• Take with or without food. Take with food if it causes an upset stomach.
• Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.
What do I do if I miss a dose? (does not apply to patients in the hospital)
• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.
• Many times this drug is taken on an as needed basis.
Are there any precautions when using this drug?
• Avoid other sources of acetaminophen. An overdose may cause problems.
• If you have an enlarged prostate, talk with your doctor.
• If you have heart disease, talk with your doctor.
• If you have high blood sugar (diabetes), talk with your doctor.
• If you have mental illness, talk with your doctor.
• If you have thyroid disease, talk with your doctor.
• If you have trouble passing urine, talk with your doctor.
• Check all drugs you are taking with your doctor. This drug may not mix well with some other drugs.
• You may not be alert. Avoid driving and doing other tasks or actions until you see how this drug affects you.
• Avoid drugs and natural products that slow your actions. These include sedatives, tranquilizers, drugs for mood, antihistamines, and other pain drugs.
• Avoid or limit drinking wine, beer, or mixed drinks to less than 3 drinks a day. Drinking too much alcohol may raise your chance of liver disease.
• Limit your use of caffeine (for example, tea, coffee, cola) and chocolate. Use with this drug may cause nervousness, shakiness, and a fast heartbeat.
• Be careful if you have G6PD deficiency. Anemia may happen.
• Tell your doctor if you are pregnant or plan on getting pregnant.
• Tell your doctor if you are breast-feeding.
What are some side effects of this drug?
• Feeling lightheaded, sleepy, having blurred eyesight, or a change in thinking clearly. Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this drug affects you.
• Nervous and excitable.
• Dry mouth. Good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help.
• Not able to sleep.
• Harm to the liver may rarely happen.
What do I need to watch for when using this drug?
• Change in the health problem being treated. Is it better, worse, or about the same?
• Dry mouth may cause more cavities. Take good care of your teeth. See a dentist often.
When do I need to call my doctor?
• If you think there was an overdose, call your local poison control center or ER right away.
• Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
• Chest pain or pressure, a fast heartbeat, or passing out.
• Very bad headache.
• Feeling very tired or weak.
• Yellow skin or eyes.
• Not able to eat.
• Any rash.
• Health problem is not better or you are feeling worse.
How do I store and/or throw out this drug?
• Store at room temperature.
• Protect from water. Do not store in a bathroom or kitchen.
General drug facts
• If you have a very bad allergy, wear an allergy ID at all times.
• Do not share your drugs with others and do not take anyone else’s drugs.
• Keep all drugs out of the reach of children and pets.
• Most drugs may be thrown away in household trash after mixing with coffee grounds or kitty litter and sealing in a plastic bag.
• In Canada, take any unused drugs to the pharmacy. Also, visit file://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Call your doctor for help with any side effects. If in the U.S., you may also call the FDA at 1-800-FDA-1088 or if in Canada, you may also call Health Canada’s Vigilance Program at 1-866-234-2345.
• Talk with the doctor before starting any new drug, including OTC, natural products, or vitamins.